Why does the pharmaceutical industry need to monitor TOC(Total organic carbon)? 

1. Cleaning in the pharmaceutical industry needs to monitor TOC

In the pharmaceutical industry, contamination by product residues and detergents can be prevented by cleaning equipment. However, there will be trace residues on the surface of the equipment after cleaning. To verify the cleaning effect, the verification methods are different for different residues. TOC analysis is an important quality control measure to ensure water purity and equipment cleanliness, and it is also a general index of the presence of organic impurities after cleaning. By analyzing the TOC content, the cleanliness of the cleaning can be further judged.

2. Water for instruments in the pharmaceutical industry needs to detect TOC
The sensitivity of analytical instruments and experimental methods has been continuously improved, and organic pollutants in pure water and ultrapure water have become a concern. High levels of organic pollutants in water can cause the following problems:

• Decreased detection sensitivity

• Poor detection limit

• Poor reproducibility 

• Elevated blank background

• Produce diffusive or non-diffusive effects

• Fouling of separation of purification media

• Microbial propagation

INNOVA Total Organic Carbon Analyzer (Analy C1500) can quickly analyze the TOC content in pure water and ultrapure water, equipped with online and offline analysis modes, which can be switched according to needs, providing solutions for TOC detection of cleaning and water in the pharmaceutical industry.

Analy C1500 Analysis Principle

Total organic carbon (TOC) is the total carbon content of organic matter in water. Under the irradiation of 185nm UV light, the organic matter will be oxidized to CO2 and H2O. Then CO2 is dissolved in water and converted into HCO3 - and CO3 2-, resulting in a change of conductivity. The total organic carbon content is calculated by detecting the trend of conductivity change.

Oxidation Cell Features

• UV oxidation direct conductivity detection without chemical reagent

• Safe and pollution-free, no routine maintenance required

• High-power 185nm UV lamp with sufficient irradiation to improve the oxidation efficiency

• Quartz glass material with the best UV transmission

• A small amount of sample can be fully oxidized in a short time to ensure analysis accuracy

• Reliable high precision conductance electrode, ensure stable and accurate data analysis

• Immersion temperature sensor provides rapid reaction

• Real-time monitor of UV lamp with fault alarm

Intelligent Human-Computer Interaction 

• 5" high-definition LCD touch screen

• Two working modes: On-line or Off-line analysis mode

• Auto start control of internal pipeline draining or cleaning

• Various numbers of analysis can be set according to different purposes

• Display operating status and alarm pop-ups

• Real time on-line viewing of data, USB port for data download

• Equipped with printer to print data

• Operation record tracking function

Innova offers a large variety of lab equipment and has been committed to delivering the highest quality lab equipment to medical device companies and laboratories worldwide. To learn more, visit our website https://www.innovabiomed.com, or contact us via info@innobiomed.com.