Vacuum freeze drying technology is a type of technology developed in recent years, which has been widely used in various industries at this stage. For the medical profession, vacuum freeze drying technology can be effectively applied in the field of biopharmaceuticals, which can further improve the quality of drug production. It can be said that freeze drying technology promotes the development of biopharmaceutical technology at this stage.

Vacuum freeze-drying technology is widely used in pharmaceuticals, and the main uses can be divided into the following aspects.

1. Application in biological products

Mainly active vaccines or blood products, these samples are required to be clean, pure, free of contaminating bacteria, and with high active vitality. There are the following kinds produced by freeze-drying method:

(1) Live bacterial vaccines, such as BCG vaccine, influenza vaccine, tuberculosis vaccine, oral dysentery live bacterial vaccine, Salmonella (Salmane), Shigella (Shigella), Streptococcus (Streptococcus) and so on.

(2) Live-virus vaccines, such as measles vaccine, influenza vaccine, yellow fever vaccine, rabies vaccine, fowl plague vaccine and so on.

(3) Other biological products, biochemical drugs such as hepatitis B surface antigen diagnostic blood cells, human leukocyte interferon, coenzyme A, adenosine diphosphate (ATF), urokinase, transfer factor, etc..

2. Applications in the production of chemicals

Most of the drugs produced by freeze-drying method are injections, with antibiotics, circulatory organs, central nervous system, vitamins and oncology drugs, such as benzylpenicillin sodium, streptomycin, erythromycin, eszopiclone, butyrophenazone, nimodipine, fleroxacin and so on.

3. Applications in the production of traditional Chinese medicine

Commonly used Chinese herbal medicines processed by freeze-drying method include ginseng, antler velvet, deer whip, Cordyceps sinensis, Chinese yam, Ganoderma lucidum, and Dihuang. In recent years, the freeze-drying method has been used to process proprietary Chinese medicines, in which the prepared proprietary Chinese medicines are impregnated, extracted, filtered, concentrated, freeze-dried and then made into powders, tablets or injections, which solves the problem of slow effect of taking tonics and traditional Chinese medicines to treat acute diseases.

The vacuum freeze drying process is particularly suitable for the following preparations.

Products with unstable physicochemical properties and poor heat resistance.

Preparations requiring high fineness.

Preparations requiring high filling precision.

Preparations that can be dissolved quickly when used.

Preparations with high economic value.

4. Application in western pharmaceutical preparations

Freeze-drying technology can be used to preserve various organs such as blood, arteries, bones, skin, cornea and nerve tissue for a long time. Because the cells of organisms are not destroyed when freeze-drying, the organisms after freeze-drying are still preserved like the original that has vitality, and if rehydrated, the organisms can be resurrected again. Such as freeze-dried bones, bone tissue can be kept in a solid state, protein denaturation is minimal, and maintain enzyme activity. It can be stored at room temperature or 4℃ for up to 2 years. It has been clinically proven that reimplantation of freeze-dried bone can be restored to normal bone physiological properties with good results.

Pharmaceutical freeze dryer is an indispensable key equipment in the pharmaceutical industry, which realizes the effective drying of drugs through freeze drying technology, protects the active ingredients of drugs, improves the stability and long-term preservation of products, and provides a reliable solution for drug production. In short, the development of freeze-drying technology to today has been very mature, and we have experienced it to people's production and life brought about by the convenience, especially in the application of pharmaceutical technology to make a more prominent contribution.